What is Cathepsin G

Cathepsin G is an enzymatic protein belonging to the peptidase or protease families.
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. Transcript variants utilizing alternative polyadenylation signals exist for this gene. Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Cathepsin G action is protease activity-dependent and was inhibited by the presence of serine protease inhibitors.  Application & Usage: Western blotting (1:500-2000). However, the optimal conditions should be determined individually.
The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In humans, it is coded by the CTSG gene. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between cells or the extracellular matrix. Cathepsin G promotes E-cadherin/catenin complex formation and Rap1 activation in MCF-7 cells, which reportedly regulates E-cadherin-based cell-cell junctions.
This product gives a single arc when tested by IEP and 2D-IEP against human Cathepsin G. Identity isconfirmed by double diffusion (Ouchterlony) verses human Cathepsin G and a known anti-humanCathepsin G.
More about: Buy Cathepsin G
Read more>> www.biochemical-bc.net