PTGIS Prostaglandin I2 synthase encodes a member of the cytochrome P450 superfamily of enzymes. Two alternative splicing products; 5624bp (coding, 1578bp ORF) and 313bp (non-coding). The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
A 1.5kb upstream sequence presents CG-rich and pyrimidine-rich regions and contains consensus sequences for the recognition sites of Sp-1, AP-2, INF-gamma responsive element, GATA, NF-kB, glucocorticoid responsive element and a CACCC box. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity.
This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. The CG-rich region presents significant promoter activity. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. It has been demonstrated that PTGIS transcription is regulated via Sp1 binding, which may affected by polymorphisms in the promoter region.
Specification: 96T 48T 0.1ml 0.2ml 1ml.
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