Breast cancer, SFasL is one of the female is common malignant tumor, its happening in the process of development, some in the regulation of the molecular mechanism of apoptosis change. Apoptosis is normal embryonic development process and in the development of adult cells cleared the normal way, the process will lead to abnormal development disorder and tumors.
Fas antigen is one of the newly discovered a cell apoptosis of information surface protein, the study found that for Fas system cell apoptosis happen laid an important mechanism based. FasL, Fas as a cell surface with a pair of membrane antigen receptors in the body's immune cell activity and the tumor cells are expressed, FasL Fas combination with trigger after a series of signal transduction inside the cell by cell apoptosis in order to maintain the body from the steady state.
Fas receptor is due to alternate joining together transcription translation is caused by the side of the area through membrane introns joining together, lack of product in translation across a cell membrane area, so a soluble secretion. Soluble FasL (sFasL) as the cell membrane surface FasL soluble form, soluble Fas (sFas) and Fas (CD95) difference is that the lost across a cell membrane, sFas through it and the ligand sFasL and inhibit sFas mediated apoptosis.
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