Neurofilament 200 are composed of three major subunits referred to as the neurofilament triplet, with molecular weights of 68 kD, 160kD and 200 kD.
Antigen:Neurofilament 200 (Phos. and Nonphos.) NF200
Immunogen: C-terminal segment of enzymatically dephosphorylated pig Neurofilament 200. Purification Purified by the goat anti-mouse IgG affinity chromatography. It shows a wide species cross-reactivity. Reacts with neurofilaments in the central and peripheral nervous system and localizes the neurofilament polypeptide.
Objective type:Human, Mouse (Murine), Rat
Antibody type: monoclonal antibody
State: Affinity purified
The antibody recognizes an epitope present on human neurofilaments 200 kDa and both bovine 160 kDa and 200 kDa neurofilaments (2). lt reacts with numerous neurites in human senile plaques and decorates neurofibrillary tangles (NFT) (i.e. On duty the pyramidal cellphones from the genus Hippocampus and on neurons of the cerebral cortex from branches of knowledge with doddery dementia of the Alzheimer’s type).
Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules.
More about: Neurofilament 200
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